The female reproductive tract microenvironment includes microorganisms, metabolites, and immune components, and the balance of the interactions among them plays an important role in maintaining female reproductive tract homeostasis and health.When any one of the reproductive tract microorganisms, metabolites, or immunity is out of balance, it will
Background Diamond-Blackfan anemia is a rare, pure red blood cell aplasia of childhood due to an intrinsic defect in erythropoietic progenitors.About 40% of patients display various malformations.Anemia is corrected by steroid treatment in more than 50% of cases; non-responders need chronic transfusions or stem cell transplantation.Defects in the R
Abstract Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion.These driver mutations can be single nucleotide variants in cancer driver genes or larger structural rearrangements called mosaic chromosomal alterations (mCAs).The factors that influence the v
Abstract Selective disturbances of semantic memory have attracted the Outbound interest of many investigators and the question of the existence of single or multiple semantic systems remains a very controversial theme in the literature.Objectives: To discuss the question of multiple semantic systems based on a longitudinal study of a patient who pr
Summary: The transitions from developing to adult quiescent and activated neural stem cells (NSCs) are not well understood.Here, we use single-cell transcriptional profiling and lineage tracing to characterize these transitions in Crossbody Bag the murine forebrain.We show that the two forebrain NSC parental populations, embryonic cortex and gangli